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目的观察二甲双胍联合门冬胰岛素对2型糖尿病患者糖代谢功能的影响。方法选取2型糖尿病患者120例,采用随机数表字法分为对照组及观察组,每组60例。对照组使用门冬胰岛素治疗,观察组在对照组基础上加用二甲双胍治疗,比较两组糖代谢功能改善情况及用药安全性。结果治疗后,观察组糖代谢功能优于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率略低于对照组,差异未见统计学意义(P>0.05)。结论 2型糖尿病患者使用二甲双胍联合门冬胰岛素治疗,可有效改善患者糖代谢功能,且不增加不良反应,用药安全性高。
Objective To observe the effect of metformin combined with aspart insulin on glycometabolism in patients with type 2 diabetes mellitus. Methods 120 patients with type 2 diabetes mellitus were selected and randomly divided into control group and observation group with 60 cases in each group. The control group was treated with insulin aspart. The observation group was treated with metformin on the basis of the control group. The improvement of glycometabolic function and medication safety were compared between the two groups. Results After treatment, the glucose metabolism in the observation group was better than that in the control group (P <0.05). The incidence of adverse reactions in the observation group was slightly lower than that in the control group (P> 0.05). Conclusion Type 2 diabetes patients treated with metformin combined with insulin aspart, can effectively improve the patient’s glucose metabolism, and does not increase adverse reactions, medication safety.