目的分析探讨Twist和E-cadherin在肾透明细胞癌组织中的表达及其与肾透明细胞癌临床病理特征的关系。方法采用免疫组化EliVisionPlus法检测48例肾透明细胞癌及20例癌旁正常肾组织中Twist和E-cadherin的表达,并结合临床病理特点分析Twist和E-cadherin表达的相关性及与肾透明细胞癌临床病理特征的关系。结果 Twist在肾透明细胞癌组织中的阳性表达率为64.58%,明显高于癌旁正常肾组织的表达率20%(P﹤0.01);Twist表达率与肾透明细胞癌病理分级、临床分期、局部淋巴结转移呈显著正相关(P均﹤0.05)。E-cadherin在肾透明细胞癌组织中的阳性表达率为33.33%,明显低于癌旁正常肾组织的表达率100%(P﹤0.01);E-cadherin表达率与肾透明细胞癌病理分级、临床分期、局部淋巴结转移呈显著负相关(P﹤0.01,P﹤0.01,P﹤0.05)。Twist和E-cadherin的表达状况与患者性别、年龄、肿瘤大小无关(P均﹥0.05)。肾透明细胞癌组织中Twist表达与E-cadherin表达呈显著负相关(P﹤0.01)。结论肾透明细胞癌组织中Twist高表达、E-cadherin低表达,并与临床病理特征有关。 Objective To investigate the expression of Twist and E-cadherin in renal clear cell carcinoma and its relationship with the clinicopathological features of clear cell renal cell carcinoma. Methods Immunohistochemical EliVisionPlus method was used to detect the expressions of Twist and E-cadherin in 48 cases of clear cell renal cell carcinoma and 20 cases of adjacent normal tissues. The correlation between Twist and E-cadherin expression and the relationship between the expression of Twist and E-cadherin Relationship between clinicopathological features and cell carcinoma. Results The positive expression rate of Twist in renal clear cell carcinoma tissues was 64.58%, which was significantly higher than that in adjacent normal renal tissues (P <0.01). The expression of Twist was correlated with the pathological grade, clinical stage, Local lymph node metastasis was positively correlated (P <0.05). The positive expression rate of E-cadherin in renal clear cell carcinoma tissues was 33.33%, which was significantly lower than that in adjacent normal renal tissues (P <0.01) There was a significant negative correlation between clinical stage and local lymph node metastasis (P <0.01, P <0.01, P <0.05). The expression of Twist and E-cadherin had no correlation with the gender, age and tumor size (all P> 0.05). There was a significant negative correlation between Twist expression and E-cadherin expression in renal clear cell carcinoma (P <0.01). Conclusion The expression of Twist and low expression of E-cadherin in renal clear cell carcinoma are closely related to clinicopathological features.