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目的观察静脉滴注用丙氨酰谷氨酰胺对恶性淋巴瘤化疗后口腔炎的临床疗效。方法 130例接受化疗的恶性淋巴瘤患者分为试验组和对照组,各65例。对照组每天3餐前后及睡前给予12.5%的碳酸氢钠溶液含漱;试验组在对照组的基础上静脉滴注丙氨酰谷氨酰胺20 g·d~(-1),2组均治疗1周。化疗结束后评价口腔黏膜炎的发生率及口腔炎治愈时间。结果试验组口腔黏膜炎发生率为35.38%,显著低于对照组的46.15%(P<0.05)。试验组Ⅲ级口腔黏膜炎愈合时间为(8.25±0.96)d,显著短于对照组的(11.17±1.47)d(P<0.05)。2组用药期间均无药物相关不良反应发生。结论静脉滴注丙氨酰谷氨酰胺联合碳酸氢钠溶液含漱对防治恶性淋巴瘤化疗后口腔炎有一定的临床疗效。
Objective To observe the clinical effect of alanine glutamine on the stomatitis after chemotherapy in patients with malignant lymphoma by intravenous drip. Methods 130 cases of malignant lymphoma treated with chemotherapy were divided into experimental group and control group, 65 cases each. In the control group, 12.5% sodium bicarbonate solution was given before and after 3 meals a day and before going to bed. The experimental group was infused with 20 g · d -1 alanylglutamine on the basis of the control group, Treatment for 1 week. Evaluation of the incidence of oral mucositis after chemotherapy and stomatitis healing time. Results The incidence of oral mucositis was 35.38% in the experimental group, which was significantly lower than 46.15% in the control group (P <0.05). The grade Ⅲ oral mucositis healing time in the experimental group was (8.25 ± 0.96) d, which was significantly shorter than that in the control group (11.17 ± 1.47) d (P <0.05). No drug-related adverse events occurred during the two groups. Conclusion intravenous infusion of alanyl glutamine combined with sodium bicarbonate solution gargle prevention and treatment of malignant lymphoma stomatitis after a certain clinical effect.