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目的探讨上海市部分地区急性散发性戊型肝炎(戊肝)病毒(HEV)型别和发病危险因素。方法用巢式RT-PCR方法检测HEV序列,并进行序列的同源性比较分析;同时采取1:2病例对照研究的方法,选取上海市3个区2003-2004年急性散发性确诊戊肝86例住院病例,分别配以本区和其他区健康人群对照组,用单因素和多因素logistic回归模型进行分析。结果病毒序列分析表明戊肝病例中的HEV病毒序列属于Ⅳ型;单因素分析结果显示居住条件、外出就餐、有海鲜河鲜食用史等均为戊肝发病的危险因素;多因素分析结果显示海鲜(生、炝)食用史(OR=7．048)是戊肝感染的危险因素。结论上海市部分地区散发性HEV流行株以Ⅳ型病毒株为主,海鲜(生、炝)食用史等是戊肝发病的危险因素。
Objective To investigate the type and risk factors of acute sporadic e-hepatitis E (HEV) in some parts of Shanghai. Methods The nested RT-PCR method was used to detect the HEV sequence, and the sequence homology comparison analysis was carried out. At the same time, a 1: 2 case-control study was performed to select the acute sporadic diagnosis of hepatitis E in 2003-2004 Cases of inpatient cases, respectively, with the district and other areas of healthy control group, using univariate and multivariate logistic regression analysis. Results The virus sequence analysis showed that the HEV virus sequence in hepatitis E cases belonged to type Ⅳ. The results of univariate analysis showed that living conditions, eating out and eating history of seafood were all risk factors for the pathogenesis of hepatitis E. The results of multivariate analysis showed that seafood Health, 炝) eating history (OR = 7.048) is a risk factor for hepatitis E infection. Conclusion The predominant strains of sporadic HEV in some parts of Shanghai are Type IV strains, and the consumption of seafood (raw and cooked) is the risk factor for the pathogenesis of.