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目的随访观察155例儿童慢性淋巴细胞性甲状腺炎(CLT)患儿,探讨儿童CLT的诊治方法。方法对7年来随访观察的CLT患儿临床症状及体征、实验室检查进行回顾性分析。结果155例CLT患儿甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)检出阳性率分别为94.2%和89.7%,表明两种抗体测定对CLT有较高的敏感性和特异性。结论认为本病一旦确诊,应积极给予甲状腺激素替代治疗,以防产生永久性甲减。
Objective To investigate the clinical data of 155 cases of children with chronic lymphocytic thyroiditis (CLT) and investigate the diagnosis and treatment of CLT in children. Methods The clinical symptoms, signs and laboratory tests of CLT children who were followed up for 7 years were analyzed retrospectively. Results The positive rates of TPOAb and TGAb in 155 CLT children were 94.2% and 89.7%, respectively, indicating that the two antibodies were highly sensitive to CLT and Specificity. Conclusions that once the diagnosis of the disease, thyroid hormone replacement therapy should be actively given to prevent permanent hypothyroidism.