一氧化氮（ＮＯ）是一种无机小分子，在体内由一氧化氮合酶（ＮＯＳ）催化Ｌ精氨酸和分子氧生成。大量实验表明，ＮＯ作为一种新型的细胞内信使分子，在机体的生理和病理调节中发挥重要作用。目前研究证实，ＮＯ参与了癫痫的发病过程，但ＮＯ在癫痫发病中的作用仍有争议。本 Nitric oxide (NO) is an inorganic small molecule that is catalyzed by nitric oxide synthase (NOS) in the body to produce L-arginine and molecular oxygen. Numerous experiments show that NO as a new type of intracellular messenger molecules, play an important role in the body’s physiological and pathological regulation. The current study confirmed that NO involved in the pathogenesis of epilepsy, but the role of NO in the pathogenesis of epilepsy is still controversial. this