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目的了解四川省泸州地区不同程度宫颈病变患者人乳头瘤病毒(HPV)感染状况及其基因型分布特点,为该地区宫颈癌的防治提供理论依据。方法采用基因芯片技术对宫颈石蜡组织及液基细胞技术所获宫颈脱落细胞进行基因分型检查。结果 652例宫颈样本中,HPV检出阳性率为52.45%(342/652),其中高危感染占80.99%(277/342),低危占30.12%(103/342),混合占11.11%(38/342)。最常见前5种高危型依次为:HPV16、52、39、58和33,最常见前3种低危型依次为HPV11、6和43。20~29和40~50年龄段HPV的总感染率较高。高危型感染在各年龄段没有显著差异,低危型感染主要集中在20~29岁,显著高于其余各年龄段(P﹤0.01)。结论泸州地区HPV有较高的高、低危型感染率,且具有独特的区域和年龄段分布特点,为本地区性传播疾病及宫颈癌早期诊断、治疗、预后评估及疫苗使用等提供重要的理论依据。
Objective To understand the status of human papillomavirus (HPV) infection and its genotype distribution in patients with cervical lesions of different degrees in Luzhou, Sichuan Province, and to provide a theoretical basis for the prevention and treatment of cervical cancer in this area. Methods Genotyping was performed on cervical exfoliated cells from cervical paraffin tissue and liquid-based cells by gene chip technique. Results Among the 652 cervical samples, the positive rate of HPV was 52.45% (342/652), of which 80.99% (277/342) were high risk, 30.12% (103/342) were low risk and 11.11% (38%) mixed / 342). The most common top five high-risk types were: HPV16, 52, 39, 58 and 33, the most common first three low-risk types were HPV11, 6 and 43.20 to 29 and 40 to 50 years of age HPV infection rate Higher. There was no significant difference in high-risk infection among all age groups. Low-risk infection mainly concentrated in 20-29 years old, which was significantly higher than the other age groups (P <0.01). Conclusion HPV infection in Luzhou has a high prevalence and low risk, and has unique characteristics of regional and age distribution. It provides important information for the early diagnosis, treatment, prognosis evaluation and vaccine use of sexually transmitted diseases and cervical cancer in this area. Theoretical basis.