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肾素和血管紧张素的遗传密码在心脏的所有部位都可被表达,此为心内合成这些蛋白质的先决条件。跳动的哺乳动物心脏具有使血管紧张素I转换成血管紧张素II的生理功能。血管紧张素II的正性肌力作用是基于直接的肌性营养作用以及时交感神经传递的易化作用。局部产生的血管紧张素可能是发生再灌注心律失常的主要因素,转换酶抑制剂在充血性心力衰竭中的独特作用,提示除了其全身血流动力学的作用之外,还有直接的心脏作用。
The genetic code for renin and angiotensin is expressed in all parts of the heart and is a prerequisite for the synthesis of these proteins in the heart. The beating mammalian heart has the physiological function of converting angiotensin I to angiotensin II. The positive inotropic effect of angiotensin II is based on immediate muscular nutrition and the facilitation of sympathetic nerve transmission in time. Locally produced angiotensin may be a major factor in the reperfusion arrhythmia, and the unique role of the ACE inhibitors in congestive heart failure suggests that in addition to its systemic hemodynamic effects, there is a direct cardial effect .