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在前期用表面化学方法进行防治成人呼吸窘迫综合征的药物制剂处方筛选基础上,通过建立尘肺动物模型,用生物发光技术从清除自由基能力角度对制剂进行处方筛选,获到了有良好表面性能和一定自由基清除能力的人工重组肺泡表面活性剂制剂处方。该制剂有待经模型动物防治试验评价。
On the basis of pre-screening prescription of drug formulation for prevention and treatment of adult respiratory distress syndrome by surface chemical method, the model of pneumoconiosis was established by bioluminescence technology from the perspective of free radical scavenging, Formulation of artificial recombinant alveolar surfactant preparations with certain free radical scavenging ability. This formulation is to be evaluated by model animal control trials.