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1981～1996年本院收治系统性红斑狼疮病人646例,现对其中死亡的48例进行死亡原因临床分析。目的提高对系统性红斑狼疮致死病因的认识,从而指导临床治疗工作,降低死亡率。方法从年龄、性别、病程、受累器官、死因等方面,观察48例系统性红斑狼疮死亡原因与临床相关因素的关系。结果总死亡率为7.43%,以病程3年组进行比较,P<0.05。死于感染占43.75%,死于系统性红斑狼疮本身占39.58%。结论感染是本组病例最主要的死亡原因,而非主要受累器官肾脏本身。各器官受累顺序依次为肾脏、血液、肺、脑、心、肝、消化道、脾。肺是最主要的受感染部位,然后依次为败血症、腹膜炎等。
From 1981 to 1996, 646 patients with systemic lupus erythematosus (SLE) were admitted to our hospital. The cause of death was analyzed in 48 of them. Objective To improve the understanding of the cause of death of systemic lupus erythematosus and guide the clinical treatment and reduce the mortality rate. Methods 48 cases of systemic lupus erythematosus death causes and clinical factors were observed from the aspects of age, sex, course of disease, affected organs and cause of death. Results The overall mortality rate was 7.43%, compared with 3-year course of disease, P <0.05. 43.75% died of infection, died of systemic lupus erythematosus itself accounted for 39.58%. Conclusion Infection is the most important cause of death in this group of patients, not the main affected organs kidney itself. The organs involved in the order of kidney, blood, lung, brain, heart, liver, digestive tract, spleen. Lung is the most affected parts, followed by sepsis, peritonitis and so on.