论文部分内容阅读
目的 :探讨 P53及 nm2 3- H1蛋白在膀胱移行细胞癌的表达及与预后的关系 :方法 :应用免疫组织化学 S- P法 ,用 P53、nm2 3- H1单抗对 68例膀胱移行细胞癌进行研究。结果 :P53蛋白阳性表达 2 3例 ( 34.3% ) ,其阳性表达与肿瘤的病理组织学分型、复发、3年生存期有关 ( P<0 .0 5 )。nm2 3- H1蛋白阳性表达 41例 ( 60 .4% ) ,其阳性表达与肿瘤的复发、浸润及转移呈负相关 ( P<0 .0 5 )。结论 :P53、nm2 3- H1可作为判断膀胱移行细胞癌恶性程度、复发、浸润及转移的指标。
PURPOSE: To investigate the expression of P53 and nm23H in bladder transitional cell carcinoma and its relationship with prognosis.Methods: Immunohistochemical S-P method was used to detect the expression of P53 and nm23H in 68 cases of bladder transitional cell carcinoma research. Results: The positive expression of P53 protein was found in 23 cases (34.3%). The positive expression of P53 protein was related to the histopathological type, recurrence and 3-year survival (P <0.05). There were 41 cases (60.4%) of nm2 3-H1 protein positive expression, which was negatively correlated with tumor recurrence, invasion and metastasis (P <0.05). Conclusion: The expression of P53 and nm2 3-H1 can be used as an indicator of malignancy, recurrence, invasion and metastasis of bladder transitional cell carcinoma.