为寻找毒性低、活性强的化合物,研究目标化合物的合成及其抗肿瘤活性。对岩白菜素分子中糖基部分进行选择性醚化和氧化,合成得到5个新的标题化合物,MTT法测定其对肿瘤细胞增殖抑制作用。结果表明,这5个新的岩白菜素衍生物对Hela人宫颈癌细胞增殖均有一定的抑制作用,且呈现浓度依赖性关系,即该类衍生物具有一定的抗肿瘤活性。 To find compounds with low toxicity and activity, the synthesis of target compounds and their anti-tumor activity were studied. Selective etherification and oxidation of the glycosyl moiety in the bergenin molecule resulted in the synthesis of five new title compounds. The inhibitory effect on the proliferation of tumor cells was determined by MTT assay. The results showed that these five new bergenin derivatives have certain inhibitory effect on Hela human cervical cancer cell proliferation in a concentration-dependent manner, that is, derivatives of this kind have certain anti-tumor activity.