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目的 :观察 6只新西兰白兔灌服克拉霉素前后对稳态时氨茶碱血药浓度及药代动力学参数的影响。方法 :采用荧光偏振免疫分析法测定氨茶碱血药浓度。实验分为两期 :Ⅰ期d 1～ 4为单独灌服氨茶碱至稳态 ;Ⅱ期为d 5～ 10 ,合用克拉霉素与氨茶碱。每次给药剂量氨茶碱为 30mg·kg- 1,克拉霉素为 5 0mg·kg- 1。对两组药物动力学参数进行统计分析。结果 :两组各药动学参数比较均无显著性差异。结论 :氨茶碱与克拉霉素合并应用不需要调整氨茶碱的用量
OBJECTIVE: To observe the effects of clarithromycin on plasma concentrations and pharmacokinetic parameters of aminophylline in 6 New Zealand white rabbits before and after oral administration of clarithromycin. Methods: The plasma concentration of aminophylline was determined by fluorescence polarization immunoassay. The experiment was divided into two phases: the first phase of d 1 ~ 4 is a single infusion of aminophylline to steady state; Ⅱ period of d 5 ~ 10, combined with clarithromycin and aminophylline. Each dose of aminophylline 30mg · kg-1, clarithromycin 50mg · kg-1. The two groups of pharmacokinetic parameters were statistically analyzed. Results: There was no significant difference in pharmacokinetic parameters between the two groups. Conclusion: The combination of aminophylline and clarithromycin does not need to adjust the amount of aminophylline