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目的 评价肾母细胞瘤术前介入性肾动脉栓塞化疗的可行性及疗效。方法 观察分析17例肾母细胞瘤患儿TACE前后临床症状的变化及反应 ,同时与 2 2例单纯手术者比较术中情况和远期疗效。观察指标有 ,肿瘤体积 ,术中情况 ,肿瘤切除。结果 TACE后肿瘤平均缩小 4 1.7%。,总有效率 76 .5 % (13/17) ;术前介入组肿瘤完全切除率、术中平均出血量、肿瘤坏死区域面积分别为 :10 0 %、(14 2 .2± 73.2 )ml、6 0 .0 % ,单纯手术组分别为 6 3.6 %、(2 5 8.2± 2 14 .4 )ml、15 .0 % ;术前介入组 15例 (15 /17)获随访 ,2年无瘤生存率 73.3% (11/15 ) ;单纯手术组 14例 (14 /2 2 )获随访 ,2年无瘤生存率 4 2 .9% (6 /14 )。结论 肾母细胞瘤TACE ,能有效杀死肿瘤细胞 ,控制肿瘤生长 ,提高肿瘤完整切除率 ,改善预后 ,无严重并发症 ,是有效的术前治疗方法
Objective To evaluate the feasibility and efficacy of interventional renal artery embolization and chemotherapy before nephroblastoma. Methods The changes and responses of clinical symptoms in 17 cases of nephroblastoma before and after TACE were observed and analyzed. The intraoperative and long-term effects were compared with those of 22 cases of simple surgery. Observed indicators are, tumor volume, intraoperative conditions, tumor resection. Results The average tumor size decreased 4 1.7% after TACE. , And the total effective rate was 76.5% (13/17). The complete resection rate, average intraoperative blood loss and tumor necrosis area of preoperative intervention group were 100%, (142 ± 73.2) ml, 60.0% of the patients in the surgery group were (36.5%), (25.28 ± 2.14.4) ml and 15.0%, respectively. Fifteen patients (15/17) in the preoperative intervention group were followed up for 2 years without tumor The survival rate was 73.3% (11/15). In the simple operation group, 14 cases (14/2 2) were followed up. The 2-year disease-free survival rate was 42.29% (6/14). Conclusion Tumor nephroblastoma TACE can effectively kill tumor cells, control tumor growth, improve tumor complete resection rate, improve prognosis, no serious complications, is an effective preoperative treatment