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近年来由于急性白血病化疗与支持疗法的进展,患者缓解期明显延长,存活率也显著提高,中枢神经系统白血病(CNL)发病数也有上升。急性淋巴细胞白血病(ALL)发生CNL者可达40～50％,有的高达81％;急性非淋巴细胞白血病(ANLL)一般为10～20％,也有低至2.5％、高达46％者。严重影响病人预后,现就CNL的发病机理、病理、临床诊治等问题综述如下。
In recent years, due to the progress of chemotherapy and supportive therapy of acute leukemia, the remission period of patients is significantly prolonged, the survival rate is also significantly increased, the incidence of central nervous system leukemia (CNL) also increased. Acute lymphoblastic leukemia (ALL) in patients with CNL up to 40 ~ 50%, and some as high as 81%; acute non-lymphocytic leukemia (ANLL) is generally 10 to 20%, but also as low as 2.5%, up to 46%. Seriously affect the prognosis of patients, now CNL pathogenesis, pathology, clinical diagnosis and treatment and other issues are summarized below.