目的观察中药抗疲1号对训练大鼠急进高原模型的肝脏组织糖原分布及代谢功能的影响,研究训练对大鼠肝脏组织的损伤及防护。方法在海拔1520m环境设实验组(EG)使用中药抗疲Ⅰ号加入常规饲料中喂养,对照组(CG)常规饲料喂养。EG、CG各40只游泳训练4周后,各选30只3h急进3850m静息1.5h,从中各选10只作为静息对照采集标本,EG、CG各20只游泳至力竭后,1、24h采集标本。结果EG与CG相比,肝脏组织糖原含量差异均有显著性。EG肝组织PAS染色肝小叶内糖原分布均匀,无明显消耗,高倍视野肝细胞索细胞内糖原分布良好;CG肝组织PAS染色淡染,肝小叶周边糖原尚存,小叶中央糖原明显减少,肝细胞内有脂肪变等。结论过度训练、改变运动集训环境或进入高海拔地区作业训练更要特别注重加强劳动和训练防护。本防护模型研究通过食品干预训练大鼠,是一种简便易行的方法。 Objective To observe the effect of anti-fatigue No.1 on liver tissue glycogen distribution and metabolic function in the rat model of rapid-impact training in training rats, and to study the injury and protection of liver tissue during training. METHODS: The experimental group (EG) was fed at an altitude of 1520 m and fed with traditional Chinese medicine anti-Fatigue I to conventional feed, and the control group (CG) was fed conventional feed. After 40 weeks of training for each of 40 EG and CG swimmers, 30 of them were selected and 3 h was rushed for 3 h at 3850 m for 1.5 h. Ten specimens were selected from the middle of each as a resting control. 20 specimens from each of EG and CG were swimming until they were exhausted. 24h specimen collection. Results Compared with CG, there was significant difference in glycogen content in liver tissue between EG and CG. The PAS staining of EG liver showed uniform distribution of glycogen in hepatic lobule without significant consumption. The glycogen distribution in hepatocyte cord cells was well distributed in high-power field; PAS staining in CG liver tissue was lightly stained, hepatic glycogen remained in hepatic lobule, and lobular central glycogen was obvious. Decreased, fatty changes in liver cells. Conclusions Over-training, changing the environment of sports training, or entering high-altitude area operations and training must pay more attention to strengthening labor and training protection. This protective model study is a simple and easy method to train rats through food intervention.