58例精神分裂症患者随机分为两组,一组采用氯丙嗪每日1次给药,另一组为分次给药,治疗8周,结果疗效相仿,显效率分别为67.8和63.3%,有效率分别为78.6和80.0%,比较疗程各阶段的疗效亦无明显差异。1次给药法的锥体外系副反应较少,但直立性虚脱的发生率较高。对1次给药法的利弊和适应症以及有关的用药问题作了简短讨论。 Fifty-eight patients with schizophrenia were randomly divided into two groups. One group was treated with chlorpromazine once daily and the other group was dividedly administered for 8 weeks. The results were similar and the effective rates were 67.8 and 63.3% , The effective rates were 78.6% and 80.0% respectively. There was no significant difference in the efficacy of different stages of treatment. One-time administration of extrapyramidal side effects less, but the higher the incidence of orthostatic collapse. A brief discussion of the pros and cons of the 1-dose method and the indications and related medication issues.