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目的:探讨心房钠尿钛ANP在高血压心力衰竭发展过程中的变化和氨氯地平保护心肌细胞的作用。方法:对大鼠行腹主动脉结扎术,术后随机选择40只大鼠分为氨氯地平(中、高、低剂量)组以及模型组,另外选取10只健康雄性SD大鼠作为假手术组。采用ELISA方法检测各组血清ANP浓度变化。结果:随着心功能不全加重,ANP水平逐渐上升。氨氯地平用药组大鼠的心功能改善明显优于模型组,ANP明显降低,且随着氨氯地平用药量上升,心功能不断改善,ANP显著下降,P<0.05。结论:对血清ANP浓度进行测定能够反映出高血压大鼠模型心室功能不全及充血性心力衰竭严重程度。而氨氯地平能够影响机体的ANP分泌对心肌细胞起到保护作用,从而有效抑制心室重构,延缓高血压心力衰竭疾病进展。
Objective: To investigate the changes of atrial natriuretic peptide ANP in the development of heart failure and the protective effect of amlodipine on myocardial cells. Methods: Aortic ligation was performed in rats. Forty rats were randomly divided into amlodipine (medium, high and low dose) group and model group. Ten healthy male SD rats were selected as sham operation group. ELISA method was used to detect serum ANP concentration changes. Results: As heart failure worsened, the level of ANP gradually increased. The improvement of cardiac function in amlodipine treatment group was significantly better than that in model group, and ANP was significantly decreased. With the increase of amlodipine dosage, heart function improved and ANP decreased significantly (P <0.05). Conclusion: The determination of serum ANP concentration can reflect the severity of ventricular dysfunction and congestive heart failure in hypertensive rat model. Amlodipine can affect the body’s ANP secretion of cardiomyocytes to play a protective effect, which effectively inhibit ventricular remodeling, delay the progression of hypertension and heart failure.