应用免疫组化ＳＰ法对３２ 例早期胃癌及癌旁粘膜和２４ 例慢性萎缩性胃炎中ｂｃｌ２ 的表达同时进行检测，结果癌旁和慢性萎缩性胃炎中不典型增生、单纯增生、腺体扩张和癌旁肠化均显示ｂｃｌ２ 高表达，与癌无显著差异（ Ｐ＞ ００５），应视作癌前病变。ｂｃｌ２ 在癌前病变和早期胃癌中的表达显著高于周围正常粘膜（ Ｐ＜００１），提示ｂｃｌ２ 高表达是胃癌发生的早期事件，在胃癌发生上起着重要作用，可作为胃癌早期诊断的可靠指标 Immunohistochemical SP method was used to detect the expression of bcl-2 in 32 cases of early gastric cancer and paraneoplastic mucosa and 24 cases of chronic atrophic gastritis. The results were as follows: atypical hyperplasia, simple hyperplasia, and glands in adjacent and chronic atrophic gastritis. Both dilatation and paracancerous lesions showed high expression of bcl-2, which was not significantly different from cancer (P>0.05) and should be considered as precancerous lesions. The expression of bcl2 in precancerous lesions and early gastric cancer was significantly higher than that in surrounding normal mucosa (P<001), suggesting that high expression of bcl2 is an early event of gastric cancer and plays an important role in the development of gastric cancer. As a reliable indicator of early diagnosis of gastric cancer