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目的:分析肿瘤外科术后药物性肝炎的病因及临床特点,以便为临床诊治提供依据。方法:将我科2011年11月~2013年10月接诊的肿瘤术后药物性肝炎患者51例作为研究对象,回顾性分析他们的临床资料,总结分析病因及临床特点。结果:51例患者中男性对于女性,大部分在术后一周发生,年龄在70岁以上者占了50%以上,为56.86%(29/51);引起本次研究病症的药物主要包括抗生素类、抗肿瘤药、中草药及解热镇痛药等;对相关因素分析可知,术前长期饮酒或者HBsAg阳性患者极易引发肝功能损害,而术前新辅助化疗引发肝损害则最为严重。结论:肿瘤外科术后药物性肝炎病因主要与用药类型、术前长期HBsAg阳性、长期饮酒、年老、术前新辅助化疗等有关,临床诊治必须对这些因素加强重视。
Objective: To analyze the etiology and clinical features of drug-induced hepatitis after tumor surgery in order to provide evidence for clinical diagnosis and treatment. Methods: Totally 51 patients with postoperative tumor of drug-induced hepatitis treated in our department from November 2011 to October 2013 were retrospectively analyzed, their etiology and clinical features were analyzed. Results: Among the 51 patients, most of them were in women one week after operation, accounting for over 50% of those over 70 years old, accounting for 56.86% (29/51). The drugs that caused the study mainly included antibiotics , Anti-tumor drugs, Chinese herbal medicine and antipyretic analgesics; analysis of relevant factors shows that preoperative long-term alcohol consumption or HBsAg-positive patients can easily lead to liver damage, and preoperative neoadjuvant chemotherapy caused the most serious liver damage. Conclusions: The etiological factors of drug-induced hepatitis after tumor surgery are mainly related to the types of drugs, long-term preoperative HBsAg positive, long-term alcohol consumption, old age and preoperative neoadjuvant chemotherapy. Clinical diagnosis and treatment must pay more attention to these factors.