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癫癎作为一种严重危害人类健康的常见病,省30%～40%癫癎患者存在不同程度的认知障碍。近年来,对癫癎患者认知功能改变的研究与干预工作受到广泛重视,但其机制仍不清楚。研究证实白介素-1(IL-1)和白介素-6(IL-6)参与认知功能。癫癎发作后引起脑组织和血液IL-1和IL-6水平升高,可能与癫癎后认知功能损害有关。本文就IL-1和IL-6与癫癎及其认知功能障碍的关系进行综述。
Epilepsy as a common disease that seriously endangers human health, 30% to 40% of patients with epilepsy have different degrees of cognitive impairment. In recent years, the study of cognitive function in patients with epilepsy has been paid more and more attention, but its mechanism remains unclear. Studies have demonstrated that interleukin-1 (IL-1) and interleukin-6 (IL-6) are involved in cognitive function. Epileptic seizures caused by elevated levels of IL-1 and IL-6 in brain tissue and blood may be related to cognitive impairment after epilepsy. This article reviews the relationship between IL-1 and IL-6 and epilepsy and their cognitive dysfunction.