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目的:观察大黄苷元注射液对颅脑损伤患者血清细胞因子及重症感染发生率的影响。方法:按随机分组法将87例格拉斯哥昏迷评分(GCS)≤10分的颅脑损伤者分为两组,治疗组47例在常规西医治疗基础上加用大黄苷元注射液;对照组40例仅用西医常规治疗。所有患者及对照组均在入院后12h取外周静脉血5mL,测定各份样本PMNL的CD11b、CD18的表达水平。在治疗7天后所有患者再重复上述过程检查PMNL的CD11b、CD18表达情况。结果:治疗组治疗后1周内清醒率、CD11b、CD18水平下降幅度均优于对照组(与本组治疗前及与对照组治疗后比较P均<0.01),且重症感染发生率低于对照组(8.51%比15.0%,P<0.05),1周清醒率高于对照组(95.74%比82.50%,P<0.05)。结论:大黄苷元注射液在治疗颅脑损伤患者时,不仅能提高其1周内清醒率,且能降低患者血清细胞因子水平,降低其重症感染发生率。
Objective: To observe the effects of rhubarb aglycone injection on the serum cytokines and the incidence of severe infections in patients with craniocerebral injury. Methods: According to randomization method, 87 cases of craniocerebral injury with Glasgow coma score ≤10 were divided into two groups. 47 cases in the treatment group were given rhubarb aglycone injection on the basis of conventional western medicine treatment. 40 cases in the control group Western medicine only conventional treatment. All patients and control group were given 5mL venous blood 12h after admission, and the expression levels of CD11b and CD18 in each sample were determined. All patients after 7 days of treatment repeat the above procedure to check the expression of CD11b and CD18 in PMNL. Results: The decrease rate of awake rate, CD11b and CD18 in treatment group within one week after treatment were all better than those in control group (P <0.01 before treatment and before treatment in control group), and the incidence of severe infection was lower than that in control group (8.51% vs 15.0%, P <0.05). The awakening rate in 1 week was higher than that in control group (95.74% vs. 82.50%, P <0.05). Conclusion: The rhubarb aglycone injection can not only improve the awakening rate in one week, but also decrease the level of serum cytokines in patients with craniocerebral injury, and reduce the incidence of severe infection.