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目的贝尔麻痹是一种常见的特发性面神经病变,导致病变侧的面部肌肉运动功能丧失。作者探讨了贝尔麻痹对大脑默认模式网络(DMN)功能连接的影响。材料与方法使用1.5 T MR成像仪获取静息态f MRI数据,包括健康志愿者35名及不同病理状态下的面瘫患者52例次。使用双重回归独立成分分析方法处理数据。结果发现面瘫不同病理状态下DMN的功能连接发生了不同的变化。在面瘫疾病早期,DMN功能连接在右侧初级感觉皮层、初级运动皮层、背外侧前额叶显著增强;在面瘫后期,DMN功能连接在双侧中扣带回、楔前叶、右侧富内侧前额叶、后扣带回显著增强;在面瘫康复后,DMN功能连接在左侧舌回、小脑显著增强。结论在面瘫不同病理阶段,DMN的功能连接存在着明显的不同,涉及到感觉运动,运动映射,情感以及认知等不同功能脑区。
PURPOSE Paralysis is a common idiopathic facial neuropathy that leads to loss of facial muscle function on the lesion side. The authors explored the impact of Bell’s paralysis on the brain’s default mode network (DMN) functional connectivity. MATERIALS AND METHODS Resting state f MRI data were acquired using a 1.5 T MR imager, including 35 healthy volunteers and 52 patients with facial paralysis under various pathologies. Data were processed using dual regression independent component analysis. The results showed that different pathological conditions of facial paralysis DMN functional connections have taken place in different changes. In the early stage of facial paralysis, DMN function is connected to the right primary sensory cortex, primary motor cortex, dorsolateral prefrontal cortex significantly enhanced; in the late facial paralysis, DMN function is connected in the bilateral cingulate gyrus, anterior wedge leaf, the right side of the rich medial forehead Leaf, back cingulate back significantly enhanced; in facial paralysis rehabilitation, DMN functional connection in the left lingual gyrus, cerebellar significantly enhanced. Conclusions There are obvious differences in the functional connection of DMN in different pathological stages of facial paralysis, involving different functional brain regions such as sensory movement, motor mapping, emotion and cognition.