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分别暴露三硝基甲苯（ＴＮＴ）、铅、黄磷的工人，空腹口服１７０ｍｇ咖啡因，约８ｈ后收集唾液，用ＨＰＬＣ法测定咖啡因含量，根据药动学公式求出唾液咖啡因清除率（ＳＣＬｃａ），同时测定其它肝功能指标。结果表明，对照组（２７例）ＳＣＬｃａ为１３４．３±５９．７ｍｇ／ｍｉｎ，ＴＮＴ接触者（３７例）为６６．５±３３．８ｍｌ／ｍｉｎ，铅接触者（３４例）为６４．１±３０．３ｍｌ／ｍｉｎ，黄磷接触者（３８例）为１４９．９±６８．７ｍｌ／ｍｉｎ。ＴＮＴ和铅接触者ＳＣＬｃａ下降（Ｐ＜０．０１），说明接触者肝代谢功能下降。黄磷接触者ＳＣＬｃａ与对照组相比差别无显著性。以对照组ＳＣＬｃａ９５％可信限作正常范围，３种接触者ＳＣＬｃａ的异常检出率均比血清谷雨转氨酶（ＳＧＰＴ）和ｒ－谷氨酸转肽酶（ｒ—ＧＴ）异常检出率为高（Ｐ＜０．０１），凡ＳＧＰＴ和（ｒ—ＧＴ）异常者ＳＣＬｃａ大多有改变。
Workers exposed to trinitrotoluene (TNT), lead and yellow phosphorus were orally administered with 170 mg of caffeine on an empty stomach, saliva was collected after about 8 hours, the caffeine content was determined by HPLC, and salivary caffeine clearance was calculated according to the pharmacokinetic formula SCLca), while measuring other indicators of liver function. The results showed that SCLca was 134.3 ± 59.7mg / min in control group (27 cases), 66.5 ± 33.8ml / min in TNT contact group (37 cases) and 64.1 ± 30.3ml / min, yellow phosphorus contact (38 cases) was 149.9 ± 68.7ml / min. TNL and lead contact SCLca decreased (P <0.01), indicating decreased hepatic metabolic function in contact. There was no significant difference in the SCLca between yellow phosphorus contacts and the control group. The control group SCLca95% confidence limits for the normal range, three kinds of contacts SCLca abnormal detection rate than the serum glutamate aminotransferase (SGPT) and r-glutamic acid transpeptidase (r-GT) abnormal detection rate was high (P <0.01). Most patients with abnormal SGPT and (r-GT) had changes in SCLca.