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全身照射疗法(TBI)是一种姑息治疗,该方法已经成功地应用在慢性淋巴细胞白血病或滤泡性淋巴瘤等无干细胞支持的放射敏感的疾病中。目前,在血液系统恶性疾病中造血干细胞移植是较为有效的治疗手段之一,其中全身放射治疗与大剂量化疗是造血干细胞移植疗法的经典预处理方案。TBI方法主要应用在造血移植环境中,具有较强的周期非特异性抗肿瘤效应和免疫抑制效能。TBI给予干细胞移植病人超过正常骨髓的辐射耐受量,通过重建病人的造血和免疫来达到治疗目的。
Total body irradiation (TBI) is a palliative treatment that has been successfully used in radiation-sensitive diseases such as chronic lymphocytic leukemia or follicular lymphoma without stem cell support. At present, hematopoietic stem cell transplantation is one of the most effective hematopoietic stem cell transplantation in the hematological malignancies. Among them, systemic radiation therapy and high-dose chemotherapy are the classic pretreatment regimens for hematopoietic stem cell transplantation. TBI method is mainly used in hematopoietic transplantation environment, has a strong cycle of non-specific anti-tumor effect and immunosuppressive efficacy. TBI gives radiation-tolerant patients with more than normal bone marrow to stem cell transplant patients for therapeutic purposes by reconstructing the patient’s hematopoiesis and immunity.