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目的： 探讨超声引导下经皮低渗热凝剂介入治疗肝癌可行性和疗效。方法： ８ 个猪肝、１６ 只兔和 ２ 只狗在超声引导下肝内注入低渗热凝剂， 并测抗体、Ｃ３、Ｃ４， 同时对２０ 例肝癌患者瘤内注入低渗热凝剂。结果： 动物肝内注入热凝剂后可见 ２ｃｍ ×３ｃｍ 凝固坏死区， 周边有包膜， 抗体、Ｃ３、Ｃ４ 升高。肝癌患者随访 ６ 月， 均健在， 治疗后肿块缩小， 血流减少或消失， ＣＴ 无强化， ＡＦＰ 下降或正常， 全身情况改善， 治疗后活检完全坏死。声像图改变与病理变化对应。结论： 超声引导下经皮低渗热凝剂介入治疗肝癌是一种安全有效的方法。
Objective: To explore the feasibility and efficacy of ultrasound-guided percutaneous hypotonic thermocoagulation for the interventional treatment of liver cancer. Methods: Eight pig livers, 16 rabbits and 2 dogs were injected with hypotonic thermocoagulant under ultrasound guidance. The antibodies, C3 and C4 were measured. In addition, hypotonic thermocoagulants were injected into the tumors of 20 patients with liver cancer. RESULTS: After injecting the thermocoagulant into the liver, the animal showed a solidification and necrosis zone of 2 cm × 3 cm, and there was an envelope surrounding the animal. The antibodies, C3, and C4 were elevated. Liver cancer patients were followed up for 6 months and were all healthy. After treatment, the tumor was reduced, blood flow was reduced or disappeared, CT was not enhanced, AFP was decreased or normal, general condition was improved, and biopsy was completely necrotic after treatment. Changes in sonograms correspond to pathological changes. Conclusion: Ultrasound-guided percutaneous hypotonic thermocoagulation is a safe and effective method for interventional treatment of liver cancer.