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心肌梗死 (心梗 )导致复杂的结构变化 ,其中左室扩张与梗死区变薄 ,是最显著的结构变化 ,可能产生心力衰竭 (心衰 )、动脉瘤形成及心脏破裂等并发症。左室重构的决定因素之一是心梗后愈合过程中细胞外间质的损伤与丢失[1] 。存在于心肌中并能降解所有心脏基质成分的基质金属蛋
Myocardial infarction (MI) leads to complex structural changes, in which left ventricular dilatation and thinning of the infarct zone are the most significant structural changes that may lead to complications of heart failure (heart failure), aneurysm formation and heart rupture. One of the determinants of left ventricular remodeling is the injury and loss of extracellular matrix during post-MI healing [1]. Matrix metal eggs that are present in the myocardium and degrade all cardiac matrix components