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目的研究中性粒细胞弹性蛋白酶(NE)在慢性阻塞性肺疾病(COPD)患者血清的表达及临床意义。方法采用酶联免疫吸附试验(ELASA)检测46例COPD患者和40例正常对照组血清NE表达水平并进行分析比较。结果 COPD患者血清NE水平高于对照组水平,差异有显著性(P<0.05);NE的表达与COPD的临床分期有关,急性加重期NE水平高于稳定期,差异有显著性(P<0.05),稳定期与对照组无明显差异(P>0.05);NE的表达与COPD的临床分级有关,Ⅳ级高于Ⅲ级,Ⅲ级高于Ⅱ级,Ⅱ级高于Ⅰ级,Ⅰ级高于对照组,差异均有显著性(P<0.05)。结论 NE表达与COPD的发生发展有一定的关系,动态测定COPD患者血清NE水平具有重要的临床意义。
Objective To study the expression of serum neutrophil elastase (NE) in patients with chronic obstructive pulmonary disease (COPD) and its clinical significance. Methods Serum levels of NE in 46 patients with COPD and 40 normal controls were detected by enzyme-linked immunosorbent assay (ELASA) and analyzed. Results The level of serum NE in COPD patients was significantly higher than that in control group (P <0.05). The expression of NE was correlated with the clinical stage of COPD. The level of NE in acute exacerbation was higher than that in control group (P <0.05) ), There was no significant difference between stable group and control group (P> 0.05). The expression of NE was related to clinical grade of COPD, grade Ⅳ was higher than grade Ⅲ, grade Ⅲ was higher than grade Ⅱ, grade Ⅱ was higher than grade Ⅰ and grade Ⅰ In the control group, the difference was significant (P <0.05). Conclusion The expression of NE is related to the development and progression of COPD. The dynamic determination of serum NE level in patients with COPD has important clinical significance.