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目的比较无慢性高血压基础疾病的早发型重度子痫前期(early onset severe preeclampsia,EOSP)患者与慢性高血压并发EOSP患者的期待治疗时间和妊娠结局差异。方法选取2012~2015年宜宾市第一人民医院收治的EOSP患者420例,其中320例无慢性高血压基础病的EOSP患者为单纯组,100例慢性高血压并发EOSP患者为高血压组,比较两组的期待治疗时间和妊娠结局。结果高血压组最高收缩压、舒张压及胎儿生长受限发生率均较单纯组高,期待治疗时间比单纯组长,低蛋白血症及肺水肿发生率比单纯组低,差异均有统计学意义(P<0.05);两组的胎盘早剥、HELLP综合征发生率、子痫发生率、围产儿死亡率、新生儿死亡率、胎死宫内发生率及新生儿窒息发生率等比较,差异无统计学意义(P>0.05)。结论慢性高血压EOSP患者较无慢性高血压基础病的EOSP患者期待治疗时间长,但通过严密监测患者的病情,可获得较好的妊娠结局。
Objective To compare the difference of expectant treatment time and pregnancy outcome between patients with early onset severe preeclampsia (EOSP) and patients with chronic hypertension complicated with EOSP without underlying chronic hypertension. Methods A total of 420 EOSP patients were selected from the First People’s Hospital of Yibin City from 2012 to 2015. Among 320 patients with EOSP who had no underlying chronic hypertension were EOSP patients and 100 were hypertensive patients with chronic hypertension complicated with EOSP, The group looked forward to treatment time and pregnancy outcome. Results The highest systolic blood pressure, diastolic blood pressure and fetal growth restriction rate in hypertension group were higher than those in simple group. The treatment time was expected to be lower than those in simple group, hypoalbuminemia and pulmonary edema, the difference was statistically significant (P <0.05). Compared with the rates of placental abruption, HELLP syndrome, eclampsia, perinatal mortality, neonatal mortality, intrauterine fetal death rate and neonatal asphyxia, The difference was not statistically significant (P> 0.05). Conclusion Patients with EOSP in chronic hypertension are expected to have longer treatment time than EOSP patients without underlying hypertension. However, better monitoring of pregnancy outcomes can be achieved by closely monitoring the patient’s condition.