肿瘤的侵袭和转移是患者死亡的最主要原因。它是一个复杂的多因素、多步骤的病理生理过程。近年来粘附分子 ICAM- 1、E- Cadhcrin、CD44v6与肿瘤的侵袭转移的关系正成为研究的重点。笔者对该 3种粘附分子与肿瘤、特别是膀胱癌的侵袭转移的关系作一综述 ,展望它们作为临床指标为 TCC的早期预防、诊断和治疗提供依据 Tumor invasion and metastasis is the leading cause of death in patients. It is a complex multi-factor, multi-step pathophysiological process. In recent years, the adhesion molecules ICAM-1, E-Cadhcrin, CD44v6 invasion and metastasis of the relationship is becoming the focus of research. The author summarizes the relationship between the three adhesion molecules and the invasion and metastasis of tumor, especially bladder cancer, and provides a basis for their clinical indications for the early prevention, diagnosis and treatment of TCC