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目的比较长效抗胆碱能药物(噻托溴铵)与缓释茶碱对于夜间哮喘控制的疗效。方法选择2014年8月至2015年8月在天津市第一中心医院呼吸科门诊就诊的哮喘症状夜间严重的60例患者为研究对象,随机分为噻托溴铵粉吸入剂组(30例)和茶碱缓释片组(30例),观察两组平均呼气峰值流速日内变异率(PEFR)、第1秒用力呼气容积(FEV_1)、第1秒用力呼气容积占预计值百分比(FEV1%)、哮喘控制测试(ACT)评分及夜间憋醒次数的变化情况。应用SPSS 21.0统计软件进行t检验。结果经过3个月治疗,两组PEFR、FEV_1、FEV_1%、ACT评分均较治疗前改善,差异均有统计学意义(P<0.05);噻托溴铵粉吸入剂组在PEFR、ACT评分、夜间憋醒次数上较茶碱缓释片组改善显著,差异均有统计学意义(P<0.05),两组在FEV_1、FEV_1%变化上差异均无统计学意义(P>0.05)。结论长效抗胆碱能药物较缓释茶碱更有助于夜间哮喘的控制。
Objective To compare the efficacy of long-acting anticholinergic drugs (tiotropium bromide) and sustained release theophylline for the control of nocturnal asthma. Methods Sixty patients with severe asthma at night from August 2014 to August 2015 in the Respiratory Clinic of the First Central Hospital of Tianjin were selected and randomly assigned to tiotropium bromide inhalation group (n = 30) And theophylline sustained-release tablets group (30 cases). The mean intra-day variation rate (PEFR), the forced expiratory volume in 1 second (FEV_1), the forced expiratory volume in 1 second (% FEV1%), asthma control test (ACT) scores and changes in the number of night arousal. SPSS 21.0 statistical software for t test. Results After 3 months of treatment, the PEFR, FEV_1, FEV_1% and ACT scores in both groups were significantly improved compared with those before treatment (P <0.05). The differences of PEFR, ACT score, There was no significant difference between the two groups in FEV_1 and FEV_1% changes (P> 0.05). There was no significant difference between the two groups in the changes of FEV_1 and FEV_1%. Conclusion Long-acting anticholinergic drugs are more helpful for the control of nocturnal asthma than theophylline.