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目的 研究血管内皮细胞生长因子 (VEGF)与增殖性细胞核抗原 (PCNA)蛋白在各级脑胶质瘤中的表达率及与胶质瘤病理分级的关系。方法 利用免疫组化方法检测 4 5例胶质瘤手术标本中VEGF与PCNA蛋白的表达水平 ,并比较二者的相关性。结果 随着胶质瘤病理级别的升高 ,VEGF及PCNA的表达率渐之升高 ,Ⅰ Ⅳ级病理分组中 ,VEGF阳性率分别为 2 2 .2 9± 7.6 4 ,5 3.75± 10 .74 ,70 .2 7± 14 .2 7,PCNA阳性率分别为 15 .86± 4 .5 5 ,32 .4 1± 7.4 4 ,4 7.92± 10 .31,且并各级之间有显著差异 (P <0 .0 5 )。结论 VEGF与PCNA蛋白的表达对判断胶质瘤病理分级及生物学行为有一定意义。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in gliomas at various stages and their relationship with the pathological grade of gliomas. Methods Immunohistochemistry was used to detect the expression of VEGF and PCNA protein in 45 cases of gliomas. The correlation between them was also compared. Results As the pathological grade of gliomas increased, the expression of VEGF and PCNA gradually increased. The positive rates of VEGF in group Ⅰ Ⅳ were respectively 2.229 ± 7.64 and 5 3.75 ± 10.74 , 70.27 ± 14.27, the positive rates of PCNA were 15.86 ± 4.55, 32.41 ± 7.44, 4.792 ± 10.31 respectively, and there were significant differences among all levels P <0. 05). Conclusion The expressions of VEGF and PCNA have certain significance in judging the pathological grade and biological behavior of gliomas.