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目的 探讨游离空肠重建长段环形缺损气管后对气管的黏液 纤毛清除功能的影响 ,为该方法应用于临床提供依据。方法 通过显微外科游离空肠联合镍钛合金网重建 12条犬气管的动物实验模型 ,纤维支气管镜下于重建气道的下切缘用注射器滴入示踪剂 ,计算示踪剂从滴入到到达声门的时间 (mucociliarytransittime ,MTT)除该段长度 (mucociliarytransportlength ,MTL) ,为黏液清除率(mucociliarytransportrate,MTR) ,对游离空肠重建 6 5cm长段环形缺损气管后新气道的黏液 纤毛清除功能进行术前 ,术后 7d、1个月、3个月、6个月多时间点研究。结果 除了术前的MTR与术后 1个月的MTR相比差异有统计学意义外 (P <0 0 5 ) ,其余术前MTR与术后 7d、3个月、6个月及术后 7d与术后 1个月、3个月、6个月相比均无统计学意义 (P >0 0 5 )。结论 游离空肠重建气管中 ,新气道的黏液 纤毛清除功能随着呼吸道炎症的消退术后 3个月恢复正常水平
Objective To investigate the effect of tracheal mucosal clearance after tracheal reconstruction of long jejunum of jejunum in free jejunum and to provide basis for its application in clinic. Methods The experimental model of 12 dogs was reconstructed by microsurgical free jejunum combined with nickel-titanium alloy mesh. The tracer was dripped into the lower margin of the reconstructed airway by fiberbronchoscope and the tracer was dripped into the tracer In addition to the mucociliary transit length (MTT), mucociliary transit time (MTT) was the mucociliary transit time (MTR), and the mucociliary clearance function of the new airway after 65 min Preoperative, postoperative 7d, 1 month, 3 months, 6 months and more time points. Results The preoperative MTR was significantly different from MTR at 1 month after operation (P <0.05). The remaining preoperative MTR was significantly higher than that at 7 days, 3 months, 6 months and 7 days after operation There was no significant difference between 1 month, 3 months and 6 months after operation (P> 0.05). Conclusion In the free jejunal reconstruction of the trachea, the mucociliary clearance of the new airway returned to its normal level at 3 months after restenosis of airway inflammation