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目的研究中药复方制剂安可梦口服液 (简称AKM)药效学作用。方法通过观察测定AKM对实验小鼠自发活动情况 ,对戊巴比妥钠阀下剂量、阀剂量小鼠睡眠时间和对硝酸士的宁致小鼠惊厥的影响 ,研究AKM镇静、催眠、抗惊厥作用。结果AKM口服液能抑制小鼠自发活动 ,对小鼠睡眠的影响与戊巴比妥钠有协同作用 ,有对抗硝酸士的宁导致惊厥发作的作用 ,且剂量越大 ,作用越明显。结论AKM口服液有明显的镇静、催眠、抗惊厥作用 ,为AKM的临床运用提供了实验研究依据
Objective To study the pharmacodynamics of AnjiMeng Oral Liquid (AKM for short). Methods AKM sedation, hypnosis and anticonvulsant were studied by observing and measuring the spontaneous activity of AKM in experimental mice, the effect of pentobarbital sodium dose, the dose of mice in valve dose, and the effect of streptozotocin-induced seizure in mice. effect. Results AKM oral liquid could inhibit the spontaneous activity of mice. The effect on sleep of mice was synergistic with that of pentobarbital sodium. It had the effect on epileptic seizure caused by strychnine, and the larger the dose was, the more obvious the effect was. Conclusion AKM oral liquid has obvious sedative, hypnotic and anticonvulsant effects, providing experimental basis for the clinical application of AKM.