[答]氯霉素对骨髓的抑制作用可分两种,一种是可逆的,一种是不可逆的。前者多见于使用剂量超过50毫克/公斤/天以上者。在这种抑制作用发生前,通常先有网状细胞值下降和血清铁值上升,以后白细胞和血小板值才开始减少。如这时查骨髓像,可发现幼红细胞内有空泡形成。关于其作用机理,国外目前已有报道, [A] chloramphenicol on bone marrow suppression can be divided into two kinds, one is reversible, one is irreversible. The former is more common in the use of doses over 50 mg / kg / day. Before this inhibitory effect occurs, there is usually a decrease in the number of reticulocytes and an increase in serum iron values, after which white blood cell and platelet values ​​begin to decrease. Such as check bone marrow like this, can be found within the red blood cells in the formation of vacuoles. About its mechanism of action, has been reported abroad,