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目的探讨较低剂量地高辛与适时追加西地兰治疗充血性心力衰竭(CHF)的疗效及中毒反应。方法采用临床对照分析将86例CHF随机分成2组,治疗组44例,较低剂量地高辛维持,适时追加西地兰;对照组:用地高辛加氢氯噻嗪。结果治疗组的疗效明显优于对照组,中毒反应发生率为6.8%和4.8%,明显低于传统负荷疗法中毒反应率的25%。结论本疗法由于有效率明显优于对照组,而且中毒反应明显低于传统疗法,因而认为,较低剂量地高辛适时追加西地兰疗法不失为治疗CHF的理想方案。同时显示:较低剂量地高辛(0.125~0.25mg)治疗心衰(CHF),能改善病人的左室功能,又能纠正神经内分泌异常,安全而有效,此点在临床上具有重要意义。
Objective To investigate the efficacy and toxicity of low dose digoxin and timely additional cedilanid treatment of congestive heart failure (CHF). Methods A total of 86 CHF patients were randomly divided into two groups according to the clinical comparative analysis. The treatment group (44 cases) was maintained at low dose of digoxin and append cedilanidone in time. The control group was given digoxin plus hydrochlorothiazide. Results The curative effect of the treatment group was obviously better than that of the control group. The incidence of poisoning was 6.8% and 4.8%, which was significantly lower than 25% of the traditional load therapy. Conclusion The treatment is obviously superior to the control group because of the effective rate, and the poisoning response is obviously lower than the traditional therapy. Therefore, it is considered that the low dose of digoxin can timely append the cedilanid therapy after treating the CHF. Simultaneously, it is clinically significant that lower doses of digoxin (0.125-0.25 mg) can improve left ventricular function and correct neuroendocrine abnormalities safely and effectively in patients with CHF.