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目的 探讨慢性病毒性肝炎血清纤维化指标III型前胶原 (PCIII) ,透明质酸 (HA)及层粘蛋白 (Ln)水平与肝纤维化程度的关系。方法 采用放射免疫分析法测定 80例慢性病毒性肝炎患者血清PCIII、HA及Ln的水平。结果 发现PCIII、HA及Ln的水平在重度慢性病毒性肝炎中均明显升高 ,与轻、中度及正常对照组相比具有显著差异 (P <0 .0 1) ,PCIII与Ln在轻度与正常对照组相比无显著差异 (P >0 .0 5 ) ,HA含量在轻、中度和正常对照组相比较有显著差异 (P <0 .0 5 )。结论 对慢性病毒性肝炎PCIII、HA及Ln的检测 ,从不同角度反映了肝纤维化的严重程度 ,避免了肝脏病理活检的创伤 ,对慢性病毒性肝炎病程发展的估计、判断预后均有一定的意义
Objective To investigate the relationship between serum fibrosis indicators type III procollagen (PCIII), hyaluronic acid (HA) and laminin (Ln) levels and the degree of liver fibrosis in patients with chronic viral hepatitis. Methods Serum PCIII, HA and Ln levels were measured by radioimmunoassay in 80 patients with chronic viral hepatitis. The results showed that the levels of PCIII, HA and Ln in severe chronic viral hepatitis were significantly increased, compared with mild, moderate and normal control group was significantly different (P <0.01), PCIII and Ln in mild and moderate There was no significant difference between the normal control group (P> 0.05) and the HA level in the mild, moderate and normal control groups (P <0.05). Conclusions The detection of PCIII, HA and Ln in chronic viral hepatitis reflects the severity of liver fibrosis from different angles and avoids trauma of liver biopsy, which has certain significance for estimating the course of chronic viral hepatitis and prognosis