家族遗传性颗粒型角膜营养不良，在1890年由Groenouw首次报道，属常染色体显性遗传，本病多在10岁以内发病，表现在角膜中央部基质浅层的点状、颗粒状混浊、病情发展缓慢，伴随终生，多无自觉症状，病情严重者，可有一定程度的视力障碍，本文报道一家系3代发病，且4个角膜病变 Family hereditary granular corneal dystrophy, first reported in 1890 by Groenouw, is an autosomal dominant inheritance, the disease more than 10 years of age onset, the performance of the central corneal stromal shallow spots, granular opacity, the disease With slow development, with life-long, many without symptoms, in severe cases, may have a certain degree of visual impairment, this article reports a family of 3 generations of onset, and 4 corneal lesions