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目的比较高原脑水肿(high altitude cerebral edema,HACE)不同治疗方案之间疗效,初步探索高原脑水肿的规范化治疗方案。方法将60例HACE患者随机平均分为A、B、C组,A组给予吸氧、地塞米松、甘露醇、速尿治疗,B组给予吸氧、地塞米松、甘露醇、乙酰唑胺治疗,C组给予吸氧、β-七叶皂甙、甘露醇、速尿治疗,并对3组的疗效进行综合评价。结果从症状缓解时间、CT影像上脑水肿征象消失时间及住院时间比较,A组均显著低于B组和C组(P<0.01);3种治疗方案安全性比较,A组副作用及并发症发生率显著低于B组及C组(P<0.05)。结论吸氧、地塞米松、甘露醇、速尿方案具有安全、疗效显著的特点,可以作为高原脑水肿规范化治疗方案加以推广。
Objective To compare the curative effects between different treatment regimens of high altitude cerebral edema (HACE) and to explore the standardized treatment plan of plateau cerebral edema. Methods A total of 60 HACE patients were randomly divided into A, B and C groups. A group was given oxygen, dexamethasone, mannitol and furosemide. Group B was given oxygen, dexamethasone, mannitol, acetazolamide C group was given oxygen, β-aescinate, mannitol, furosemide treatment, and the comprehensive evaluation of the efficacy of the three groups. Results Compared with group B and C (P <0.01), the time to symptom relief, the disappearance time of CT edema and the length of hospital stay in group A were significantly lower than those in group C The incidence was significantly lower than those in group B and C (P <0.05). Conclusion Oxygen inhalation, dexamethasone, mannitol and furosemide have the characteristics of safety and curative effect, which can be used as the standardized treatment plan of plateau cerebral edema.