论文部分内容阅读
目的 比较间质微血管参数在鼻咽癌多阶段形态发生过程中的差异 ,并探讨间质微血管生成对鼻咽癌病理发展和癌生物学行为的影响作用 .方法 分别选择经病理确诊 (同时分组 )为 1正常鼻咽粘膜上皮标本 ;2单纯增生 /化生的鼻咽粘膜上皮标本 ;3异型增生 /化生的鼻咽粘膜上皮标本 ;4鼻咽癌上皮标本各 2 5例 ,进行间质微血管的免疫组化染色和计算机图像定量分析 .测试和计算 4个参数 :微血管计数 ,微血管相对面积 ,平均微血管面积和平均微血管周长 ,并比较这些参数在上述 4组间的差异 .结果 3组的微血管计数与微血管相对面积显著高于 2组 ,而平均微血管面积和平均微血管周长均显著低于 2组 .上述 4个参数在 1 2组之间及 34组之间差异无显著性 ,但在 2、3组之间的差异则有显著性 (P<0 .0 1 ) .结论 异型增生 /化生的鼻咽上皮组织细胞可能已经具有了癌细胞的某些生物学行为 ,如产生多种肿瘤血管生长因子 (TAF) ,刺激间质微血管的生长 ,为其早期转移与浸润做准备 ,而间质微血管的增生也可能是鼻咽上皮癌变转化过程的必需的病理改变 ,提示在早期的鼻咽癌筛查过程中 ,应注意跟踪鼻咽上皮异型增生 /化生的高危人群
Objective To compare the difference of interstitial microvascular parameters in the multiphasic morphogenesis of nasopharyngeal carcinoma and to explore the effect of interstitial microangiogenesis on the pathological development and biological behavior of nasopharyngeal carcinoma.Methods Were selected pathologically confirmed (at the same time) 1 normal nasopharyngeal mucosa epithelial specimens; 2 simple hyperplasia / metaplasia nasopharyngeal epithelial specimens; 3 dysplasia / metaplasia nasopharyngeal mucosa epithelial specimens; 4 nasopharyngeal epithelial specimens of 25 cases of interstitial microvascular Immunohistochemical staining and computer image quantitative analysis.Four parameters were tested and calculated: microvessel count, microvessel area, mean microvessel area and mean microvessel perimeter.Results The differences of these parameters among the above four groups were compared.Results Three groups of The relative area of microvessel count and microvessel was significantly higher than that of two groups, but the average microvessel area and average microvessel circumference were significantly lower than those of group 2. There was no significant difference in the above four parameters between group 12 and group 34, The difference between the three groups was significant (P <0.01) .Conclusion The dysplasia / metaplasia nasopharyngeal epithelial cells may already have cancer cells Some of the biological behavior, such as the production of a variety of tumor angiogenic growth factor (TAF), stimulate the growth of interstitial microvessels for its early metastasis and infiltration in preparation, and interstitial microvascular hyperplasia may also be nasopharyngeal carcinogenesis The necessary pathological changes, suggesting that in the early screening of nasopharyngeal carcinoma, should pay attention to tracking the high risk of nasopharyngeal epithelial dysplasia / metaplasia