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左旋咪唑是目前首选的驱蛔虫药物,但常见副作用有头痛、头晕、失眠、恶心、腹部不适等症状,致高热反应报道较少。作者遇到2例肠道蛔虫症患者服左旋咪唑后,出现高热反应。例1,8岁,服左旋咪唑50mg,12小时出现高热反应,体温达39.8℃;例2,38岁,服左旋眯唑150mg,14小时后体温达39.3℃,经对症治疗1天后体温降至正常。2例患者服药前体温均正常。该药是一种免疫调整剂,对T淋巴细胞和吞噬细胞有促进作用,从而提高迟发型超敏反应。
Levamisol is currently the preferred roundworm drug, but common side effects are headache, dizziness, insomnia, nausea, abdominal discomfort and other symptoms, resulting in less reported hyperthermia. The authors encountered 2 cases of intestinal ascariasis patients taking levamisole, the emergence of hyperthermia. Example 1,8 years old, taking levamisole 50mg, 12 hours of high fever reaction, body temperature of 39.8 ℃; cases 2,38 years old, taking levodamine 150mg, 14 hours after the body temperature of 39.3 ℃, after symptomatic treatment for 1 day the body temperature dropped to normal. Two patients before taking the body temperature were normal. It is an immunomodulatory agent that promotes T-lymphocytes and phagocytes and improves delayed-type hypersensitivity.