本研究的目的主要侧重服药者钴胺(Vit B_(12))代谢,发病率,病因及钴胺缺乏的某些临床表现。作者对101例OC服药妇女(平均年龄30.4岁)和113例对照组进行了比较,服药者血清(S)-钴胺浓度和S-未饱和B_(12)结合力(UBBC)有明显降低。服药者更常表现为低浓度的S-钴胺(<200pmol/L)。不过,特别低浓度(<150pmol/L)的发生率并未增加。为了研究可能的剂量依赖影响,27名因 The aim of this study was to focus on the clinical manifestations of the metabolic, morbidity, etiology, and Cobalamin deficiency of the medication cobalamin (Vit B_ (12)). The authors compared 101 women with OC (mean age 30.4 years) and 113 controls with significantly lower concentrations of serum S -cobalamin and S- B 12 binding (UBBC). Drug users more often showed low concentrations of S-cobalt amine (<200 pmol / L). However, the incidence of particularly low concentrations (<150 pmol / L) did not increase. In order to investigate the possible dose-dependent effects, 27 patients