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用免疫组织化学方法研究ｒａｓ癌基因产物ｐ２１蛋白在５８例人肺癌中的表达。结果：ｐ２１蛋白在肺鳞癌中表达最高，阳性率８１．５％；在肺腺癌中表达较低，为６５．２％；２例大细胞肺癌和１例肺腺鳞癌均为阳性；５例小细胞肺癌均为阴性。总阳性率为６８．９％，但在非小细胞肺癌则为７５．０％。Ｐ２１蛋白是非小细胞肺癌的一个较好的标志物。在高分化肺癌中ｐ２１蛋白的阳性率为８５．７％，在中、低分化的肺癌中，则分别为７５．０％和６６．７％，三者之间均无显著性差异。但在高分化肺癌，强阳性率显著高于中、低分化肺癌。提示肺癌中ｐ２１蛋白的表达和组织分化程度有一定的关系。
Immunohistochemistry was used to study the expression of ras oncogene product p21 protein in 58 cases of human lung cancer. Results: The expression of p21 protein was highest in lung squamous cell carcinoma, the positive rate was 81.5%, and it was lower in lung adenocarcinoma, which was 65.2%. Two cases of large cell lung cancer and one case of lung adenosquamous carcinoma were positive. 5 cases of small cell lung cancer were negative. The overall positive rate was 68.9%, but it was 75.0% in non-small cell lung cancer. P21 protein is a better marker for non-small cell lung cancer. The positive rate of p21 protein in well-differentiated lung cancer was 85.7%. In moderately and poorly differentiated lung cancer, it was 75.0% and 66.7%, respectively. There was no significant difference among the three. However, in highly differentiated lung cancer, the strong positive rate was significantly higher than that of poorly differentiated lung cancer. It is suggested that there is a certain relationship between the expression of p21 protein and the degree of histological differentiation in lung cancer.