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目的:研究毛冬青注射液的安全性,为临床合理用药提供依据。方法:通过豚鼠主动过敏试验(ASA)和被动皮肤过敏试验(PCA),考察过敏反应;通过体外溶血试验,观察溶血和凝聚现象;通过肌肉和血管等局部刺激试验,考察对肌肉和血管的局部刺激作用。结果:豚鼠主动过敏试验及被动皮肤过敏试验均未见过敏反应;体外溶血试验未见溶血和凝聚现象;局部刺激试验未见刺激反应。结论:本批研究的毛冬青注射液安全性较好。
Objective: To study the safety of Mao Dongqing injection and provide the basis for clinical rational drug use. Methods: Allergic reactions were investigated by guinea pig active allergy test (ASA) and passive skin allergy test (PCA). Hemolysis and cohesion were observed by hemolysis test in vitro. Local muscle and blood vessels Stimulation. Results: There was no anaphylactoid reaction in guinea pig active allergy test and passive skin allergy test. No hemolysis and coagulation were found in in vitro hemolysis test. No stimulation reaction was found in local irritation test. Conclusion: Mao Dongqing injection in this batch is safe.