抑制乙酰胆碱酯酶可以使乙酰胆碱浓度长期增加,可有效地预防自主神经失调与减轻炎症,有益于高血压合并心血管病患者。研究者研究作用于中枢和(或)外周的长效抗乙酰胆碱酯酶药,即多奈哌齐和吡啶斯的明,对自发性高血压大鼠(spontaneous hypertensive rats,SHR)的动脉压、交感迷走神经平衡、血浆细胞因子水平与心肌重塑的作用。方法:在高血压发生前用多奈哌齐或吡啶斯的明进行慢性治疗。每隔4周用体积描记仪测量动脉压。在16周的治疗结束时,用阿托品评价心脏迷走神经张力;对动脉压和脉冲 Inhibition of acetylcholinesterase acetylcholine concentration can be long-term increase, which can effectively prevent autonomic dysfunction and reduce inflammation, beneficial to patients with hypertension and cardiovascular disease. The researchers studied long-acting anti-acetylcholinesterase drugs acting at the central and / or peripheral periphery, ie donepezil and pyridostigmine, on arterial pressure, sympathetic vagal balance in spontaneously hypertensive rats (SHR) Plasma levels of cytokines and myocardial remodeling. Methods: Chronic treatment with donepezil or pyridostigmine was performed before the onset of hypertension. Arterial pressure was measured with a plethysmograph every 4 weeks. Cardiac vagal tone was assessed with atropine at the end of 16 weeks of treatment; arterial pressure and pulse