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胰岛素样生长因子1(ｉｎｓｕｌｉｎｌｉｋｅｇｒｏｗｔｈｆａｃｔｏｒ1,ＩＧＦ1)和胰岛素高度同源,它们可以通过自己的受体,即ＩＧＦ1受体(ＩＧＦ1Ｒ)和胰岛素受体(ＩＲ)发挥生物学效应。ＩＲ和ＩＧＦ1Ｒ都是α2β2跨膜糖蛋白,在β亚单位都有酪氨酸蛋白激酶区。通常人们认为,Ｉ
Insulin-like growth factor 1 (IGF1) is highly homologous to insulin and exerts biological effects through its own receptors, the IGF1 receptor (IGF1R) and insulin receptor (IR). Both IR and IGF1R are α2β2 transmembrane glycoproteins with tyrosine protein kinase domains in the β subunit. Usually people think that I