基于类淋巴系统机制治疗阿尔茨海默病的研究进展

来源 :中国神经免疫学和神经病学杂志 | 被引量 : 0次 | 上传用户：zhang2jie

【摘要】

：

阿尔茨海默病(Alzheimer disease,AD)是一种起病隐匿,呈进行性发展的神经系统退行性疾病.近些年,越来越多的研究发现类淋巴系统与AD中的异常蛋白清除障碍密切相关.本文总体阐述了类淋巴系统的发现及其与AD的关系,重点对其对脑内β-淀粉样蛋白(amyloid-beta protein,Aβ)、tau蛋白的清除功能及影响因素,以及基于类淋巴系统机制治疗AD的最新研究成果进行综述.

【作者】

：

路正钊路欣李峰

【机构】

：

100070 首都医科大学,首都医科大学附属北京天坛医院;100069 首都医科大学基础医学实验教学中心形态学实验室;100069 首都医科大学神经生物学系北京脑重大疾病研究院北京神经再生修复研究重点

【出处】

：

中国神经免疫学和神经病学杂志

【发表日期】

：

2022年2期

【关键词】

：

阿尔茨海默病类淋巴系统 β-淀粉样蛋白水通道蛋白4 睡眠

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Emerging blood exosome-based biomarkers for preclinical and clinical Alzheimer 's disease: a me

Blood exosomes, which are extracellular vesicles secreted by living cells into the circulating blood, are regarded as a relatively noninvasive novel tool for monitoring brain physiology and disease states. An increasing number of blood cargo-loaded exosom

期刊

Alzheimer's diseaseamyloid-βbiomarkersbloodexosomesextracellular vesic

Chemically oligomerizable TDP-43: a novel chemogenetic tool for studying the pathophysiology of amyo

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the progressive loss of both upper and lower motor neurons. Most ALS cases are sporadic, but approximately 5–10％ of patients have a familial background. To dat

期刊

novelamyotrophicchemicallychemogeneticlateraloligomerizablepathophysiology

Non-canonical role of the ATR pathway in axon regeneration as a mechanosensitive brake

DNA damage has been linked to neuropathology. Diverse DNA damage response (DDR) pathways help preserve DNA integrity in the nervous system during both the developmental and mature stages. Mutations of factors in various signaling pathways responsive to di

期刊

regenerationpathwayrolechanaxonbrakenon-canonicalnosesensitive

The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer 's dis

Neurovascular dysfunction, as an integral part of Alzheimer\'s disease, may have an important influence on the onset and progression of chronic neurodegenerative processes. The blood- brain barrier (BBB) pathway is one of the main pathways that mediates

期刊

Alzheimer's diseaseamyloid betaAβ clearanceblood-brain barriercerebral

The uPA/uPAR system in astrocytic wound healing

The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the wou

期刊

astrocyteslipoprotein receptor-related protein 6plasminurokinase receptoruro

Neuroprotection and neuroregeneration: roles for the white matter

Efficient strategies for neuroprotection and repair are still an unmet medical need for neurodegenerative diseases and lesions of the central nervous system. Over the last few decades, a great deal of attention has been focused on white matter as a potent

期刊

Alzheimer's diseasemultiple sclerosisoligodendrocyte precursor cellsspin

Verapamil, a possible repurposed therapeutic candidate for stroke under hyperglycemia

Admission hyperglycemia is an independent predictor, that contributes to hemorrhagic transformation (HT), and worsened functional outcome following reperfusion therapy with tissue plasminogen activator (tPA) in ischemic stroke. Clinical studies have revea

期刊

verapamilstrokecandidatehyperglycemiapossiblerepurposedtherapeuticunder

Targeting O-GlcNAcylation in ischemic stroke

Ischemic stroke is a common and often devastating disease that primarily affects the elderly. Treatment currently consists predominantly of acute thrombolysis and/or thrombectomy to restore blood flow. This reperfusion therapy, however, is only accessible

期刊

strokeischemico-glcnacylationtargeting

Beyond vertebrates: the amphioxus as a relevant model system to explore the formation, organization,

The neuromuscular junction (NMJ) is the peripheral synapse controlling muscle contraction and coordinated movement in a wide variety of animals. In humans, the mature NMJ is the primary target of morphological disassembly and functional decline in several

期刊

regenerationbeyondsystemmodelamphioxusexploreformationneuromuscularorgan

经基因检测诊断的神经元核内包涵体病一例

1病例报告患者女,65岁.“意识障碍、发热1 d余”于2019-9-4入院.患者9月3日出现口吐白沫,意识模糊,但呼之可应,有小便失禁,无肢体抽搐,遂送至当地医院就诊,行头部CT检查未见脑出血,最高体温达39.5℃.考虑“脑血管意外”,给予营养神经、护胃、补液、降温等处理后症状未见缓解,当天20点左右患者意识障碍加重,呼之不应,遂转至作者医院就诊.

期刊

神经元核内包涵体病基因检测

基于类淋巴系统机制治疗阿尔茨海默病的研究进展

与本文相关的学术论文