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目的分析表皮生长因子受体(EGFR)和雌激素受体β(ERβ)在非小细胞肺癌(NSCLC)组织中的表达,以进一步探讨EGFR和ERβ与非小细胞肺癌发生、发展的关系以及二者的相关性。方法采用MaxVision免疫组化技术检测59例NSCLC石蜡包埋组织中EGFR和ERβ的表达。结果①EGFR在NSCLC中的阳性表达率为64.4%(38/59),ERβ在NSCLC中的阳性表达率为45.8%(27/59)。在癌旁组织中未见二者表达。②EGFR阳性表达与肿瘤组织的临床分期及有/无淋巴结转移相关,与性别、年龄、肿瘤大小、组织学类型、分化程度及吸烟状况无关;ERβ阳性表达与NSCLC组织学类型有关,在腺癌组织中的表达明显高于鳞癌,与性别、年龄、肿瘤大小、组织分化程度、临床分期、淋巴结转移及吸烟状况无关。③腺癌中EGFR和ERβ阳性表达与鳞癌相比差异显著。结论本组资料显示,EGFR阳性表达提示预后不良;EGFR和ERβ可能在肺癌,尤其是腺癌的发生发展中发挥协同作用,由此可以通过同时靶向2个信号通路来治疗NSCLC。
Objective To analyze the expression of epidermal growth factor receptor (EGFR) and estrogen receptor β (ERβ) in non-small cell lung cancer (NSCLC) tissues to further explore the relationship between EGFR and ERβ and the occurrence and development of non-small cell lung cancer The relevance of the person. Methods MaxVision immunohistochemistry was used to detect the expression of EGFR and ERβ in 59 NSCLC paraffin-embedded tissues. Results ① The positive expression rate of EGFR in NSCLC was 64.4% (38/59). The positive expression rate of ERβ in NSCLC was 45.8% (27/59). No expression in both adjacent tissues. ② The positive expression of EGFR was related to the clinical stage and / or lymph node metastasis of tumor tissues, but not to the gender, age, tumor size, histological type, differentiation and smoking status. The positive expression of ERβ correlated with the histological type of NSCLC. The expression was significantly higher than squamous cell carcinoma, regardless of gender, age, tumor size, degree of tissue differentiation, clinical stage, lymph node metastasis and smoking status. ③ The positive expression of EGFR and ERβ in adenocarcinoma was significantly different from that in squamous cell carcinoma. Conclusion The data of this group show that the positive expression of EGFR indicates the poor prognosis. EGFR and ERβ may play synergistic roles in the development of lung cancer, especially adenocarcinoma. Therefore, NSCLC can be treated by simultaneously targeting two signaling pathways.