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目的观察卡介菌多糖核酸联合重组人干扰素α-2b凝胶对尖锐湿疣(CA)CO2激光治疗术后复发预防作用。方法选取皮肤科门诊治疗的CA患者88例,随机分为观察组(n=44例)与对照组(n=44例)。两组患者均予以CO2激光治疗,并予以外搽红霉素软膏预防感染。观察组患者予以卡介菌多糖核酸联合重组人干扰素α-2b凝胶治疗,对照组予以单纯重组人干扰素α-2b凝胶,其中卡介菌多糖核酸针1 mL肌注,隔日1次;重组人干扰素α-2b凝胶局部涂擦,2次/d,两组均连用4周。观察两组患者治疗后随访3个月内的复发率和治疗期间的药物不良反应。结果治疗后随访3个月,观察组患者的复发率明显低于对照组(29.55%vs 11.36%)(χ2=4.47,P<0.05)。观察组和对照组患者治疗期间出现分别药物不良反应4例(9.09%)和2例(4.55%),症状均较轻微,两组患者治疗期间药物不良反应比较差异无统计学意义(χ2=0.18,P>0.05)。结论卡介菌多糖核酸联合重组人干扰素α-2b凝胶预防CA激光治疗术后复发的疗效较确切,能明显降低其复发率,安全性较好,为预防CA的复发提供一种新的选择。
Objective To observe the preventive effect of BCG polysaccharide nucleic acid combined with recombinant human interferon α-2b gel on postoperative recurrence of condyloma acuminatum (CA) CO2 laser. Methods Eighty-eight patients with CA in dermatology clinic were randomly divided into observation group (n = 44) and control group (n = 44). Two groups of patients were given CO2 laser treatment, and apply Waicha erythromycin ointment to prevent infection. Patients in the observation group were treated with BCG-polysaccharide nucleic acid combined with recombinant human interferon alpha-2b gel, and the control group was given recombinant human interferon alfa-2b gel. The BCG-PSN 1 mL intramuscular injection was intramuscularly injected once every other day ; Recombinant human interferon α-2b gel rubbed locally, 2 times / d, both groups were used for 4 weeks. The relapse rate within 3 months and the adverse drug reaction during the treatment were observed in two groups after treatment. Results The patients were followed up for 3 months after treatment. The recurrence rate in the observation group was significantly lower than that in the control group (29.55% vs 11.36%, χ2 = 4.47, P <0.05). There were 4 adverse drug reactions (9.09%) and 2 (4.55%) adverse reactions in observation group and control group during treatment, respectively. The symptoms were mild and there was no significant difference between the two groups in the adverse drug reaction (χ2 = 0.18 , P> 0.05). Conclusion The combination of BCG polysaccharide nucleic acid and recombinant human interferon alpha-2b gel in the prevention of recurrence after CA laser treatment is more effective and can significantly reduce its recurrence rate and safety, which provides a new method to prevent the recurrence of CA. select.