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目的观察哌拉西林联合阿奇霉素治疗新生儿肺炎的临床疗效。方法将90例新生儿肺炎患儿随机分为观察组和对照组各45例,对照组给予单纯哌拉西林治疗,观察组在对照组的基础上给予阿奇霉素治疗,比较2组患者临床疗效及对胃肠道菌群的影响。结果观察组总有效率为88.89%高于对照组的86.67%,但差异无统计学意义(P>0.05)。观察组患儿治疗后的双歧杆菌、拟杆菌、真杆菌、肠球菌、乳酸杆菌的菌群数均明显低于对照组,差异均有统计学意义(P<0.05)。结论对于新生儿肺炎的治疗,哌拉西林联合阿奇霉素治疗效果无明显改善,对患儿肠道菌群影响较大。
Objective To observe the clinical efficacy of piperacillin combined with azithromycin in the treatment of neonatal pneumonia. Methods Ninety children with neonatal pneumonia were randomly divided into observation group and control group, 45 cases in each group. The control group was treated with piperacillin alone. The observation group was given azithromycin on the basis of the control group. The clinical efficacy and Effects of gastrointestinal flora. Results The total effective rate of observation group was 88.89% higher than 86.67% of control group, but the difference was not statistically significant (P> 0.05). The number of bacteria in Bifidobacterium, Bacteroides, Eubacterium, Enterococcus and Lactobacillus in the observation group was significantly lower than that in the control group (P <0.05). Conclusion For the treatment of neonatal pneumonia, piperacillin combined with azithromycin no significant improvement in the treatment of children with intestinal flora.